CERC-802

Monosaccharide substrate replacement therapy for an ultra-rare Congenital Disorder of Glycosylation

CERC-802

Targeting the Glycosylation Defects associated with Mannose-Phosphate Isomerase Deficiency

CER-802 is an ultra-pure oral formulation of D-Mannose currently in development for the treatment of Mannose Phosphate Isomerase (MPI) deficiency, also known as MPI-CDG.

Attributes
of CERC-802

  • High Purity and Quality
  • Ease of use and administration
  • Documented efficacy and safety in published literature
  • Orphan Drug and Rare Pediatric Disease Designation
  • Potential for Insurer Reimbursement

About MPI Deficiency

Currently there is no approved product for the treatment of MPI-CDG

MPI deficiency is caused by loss of function mutations in the MPI gene encoding an enzyme responsible for the conversion of fructose-6-phosphate to mannose-6-phosphate, eventually providing GDP-mannose as a donor substrate for glycoprotein synthesis.

We believe that substrate replacement with CERC-802 in patients with MPI Deficiency should facilitate the synthesis of GDP-mannose via compensatory pathways, thereby restoring the ability to produce mannose-derived glycans.

Mechanism of Action

CERC-802 is an ultra-pure formulation of D-mannose that serves as a substrate replacement therapy. Oral administration of D-mannose replenishes critical metabolic intermediates, reduced or absent due to a genetic mutation, to support glycoprotein synthesis, maintenance and function.